Comic Sans as (In)Compatibility Test
In "Write Me a Love Letter in Mrs. Eaves Ligatures," Squid and Beer considers (based on personal experience) the use of Comic Sans in email .sigs as a serious romantic incompatibility marker:
I was having dinner with the aforementioned Matthew a couple weeks ago when this topic, and that of an ex boyfriend came up. “He signed his emails with Comic Sans,” Matthew said. I nearly fell off my precariously perched barstool. “What?” he followed, “I thought you knew and liked him anyway.”
[via Typophile]