Laboratory of Molecular Neuroscience

Dr. Jon-Paul Bingham

Assistant Research Professor

B.Sc. (Griffith University, Brisbane, Australia, 1989-1991)
Thesis Title: Preliminary examination of toxins derived from Conus marmoreus and related species
Majors: Biochemistry, Biological Chemistry and Physiology
B.Sc. (Hons.) (Griffith University, Brisbane, Australia, 1992)
Thesis Title: Toxins from Conus
Honors major: Clinical Chemistry
Ph.D. (University of Queensland, Brisbane, Australia, 1993-1998, awarded 1999)
Thesis Title: Novel Toxins From the Genus Conus - From Taxonomy to toxins

Publications/Presentations (last 5 years):

"Cone shells, condoms and cod liver oil - The study of the milked venom from toxic carnivorous snails" - February 24, 2005, University of Pennsylvania, hosted by the Departments of Chemistry and Biochemistry and Molecular Biophysics.

"Toxin Bio-engineering: Chemical Advance in Toxin-Fluorophore design, synthesis and application" - September 6, 2005, The University of Melbourne, hosted Biochemistry and Molecular Biology and Bio21 Institute of Molecular Science and Biotechnology.

Krishnan M. N., Bingham, J-P., Lee, S. H., Trombley, P. and Moczydlowski E. (2005) Functional Role and Affinity of Inorganic Cations in Stabilizing the Tetrameric Structure of the KcsA K+ Channel. J Gen Physiol.;126(3):271-83.

Bingham, J.P., Broxton, N.M., Livett, B.G., Down, J.G., Jones, A. and Moczydlowski, E.G. (2005) Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study. Anal Biochem. 338: 48-61.

Jakubowski, J.A., Keays, D.A., Kelley, W.P., Sandall, D.W., Bingham, J-P., Livett, B.G., Gayler, K.R. and Sweedler, J.V., (2004) Determining Sequences and Post-Translational Modifications of Novel Conotoxins in Conus victoriae Using cDNA Sequencing and Mass Spectrometry. Rapid communications in Mass. Spect; 34: 548-557.

Duda , T.F. Jr. Bingham, J.P., Livett, B.G. Kohn, A.J., Massilia, G. R., Schultz J.R., Down J., Sandall, D., Sweedler J.V. (2004) How much at risk are cone snails? Science. 2004 Feb 13;303(5660):955-7

Marshall, J., Kelley, W.P., Rubakhin, S. S., Bingham J-P., Sweedler and Gilly W.F. (2002) Anatomical Correlates of Venom Production in Conus californicus.The biological Bulletin 203, p 27-41

Sandall, D.W., Satkunanathan, N., Bingham, J-P., Moczydlowski, E., Down, J.G., Livett, B.G. and Gayler, K.R. (2002) Alpha-conotoxins from Conus anemone. Proc. 6th Asia-Pacific Congress on Animal, Plant and Microbial Toxins. Int. Soc. Toxinology, Symposium 19, Paper 2, Cairns, July 8-12, 2002, p. 85.

Bingham, J.-P., Burlingame, A., Moczydlowski, E., Gilly, W.F. (2000) A new highly selective conotoxin from Conus californicus that targets voltage-gated neuronal Na+ channels of squid. Journal of General Physiology. 116:12a-13a.

Publications in International and Local Conference Proceedings and Posters

Krishnan, M.N., Bingham, J-P., Lee, S.H., Trombley, P. and Moczydlowski, E.G. (2005) Function and Affinity of Inorganic Cations in Stabilizing the Tetrameric Structure of the KcsA K+ Channel, 49th Annual Biophysical Society Meeting, Long Beach, California.

Bian, S., Bingham, J-P., Yan, Y., Sigworth, F., Moczydlowski, E. BK Channel Clustering On HEK293 Cells. Abstracts of the Biophysical Society 48th Annual Meeting, Feb. 14-18, 2004, Baltimore, Maryland. Biophysical Journal Supplement, Jan. 2004, Vol. 86(1), Part2 of 2, p430a.

Bingham, J-P., Bian, S., and Moczydlowski E. (2003) Synthesis of iberiotoxin-D19K-LC-Biotin: application to BK channels. Biophys. J. 84: abstract.

Bingham, J.-P., Whittal, R., Semchuk, P., Moczydlowski, E., (2002) The Milked venom from Conus geographus holds many surprises. 6th Asia-Pacific Congress on Animal, Plant and Microbial toxins, Cairns, Australia.

Sandall, D., Keays, D., Down, J., Bingham, J., Livett, B. and Gayler, K. (2001) Conotoxin diversity in venom from Australian Cone shells. Proc. 26th Annual Conference on Protein Structure and Function, 7-11 February, Lorne, Australia, 26: A56.

Bingham J-P, Medzihradszky K. F., Gilly W. F. and Burlingame A. L. (1999) The Venom of Conus californicus - its complexity and diversity as studied by various methods of Mass Spectrometry. UCSF Dept. meeting. Asilomar CA.